Title:
データ解析装置
Document Type and Number:
Japanese Patent JP6908136
Kind Code:
B2
Abstract:
According to the present invention, a first multivariable analysis processing unit (24) executes, for each sample, a first step PLS regression analysis by taking, as an explanatory variable, mass spectral data obtained for each of a plurality of measurement points in a measurement area and by taking, as an explained variable, a pixel value of a pixel corresponding to each measurement point in a fluorescent image obtained by fluorescence-labeling and capturing an image of a specific compound, and obtains a regression coefficient matrix. A second multivariable analysis processing unit (25) executes a second step PLS regression analysis by taking, as an explanatory variable, a result obtained by integrating a plurality of one-dimensional regression coefficient matrices obtained for a plurality of samples and by taking, as an explained variable, information indicating the severity of cancer in each sample as information indicating a state of each sample, and obtains a regression coefficient matrix again. Accordingly, new information, which is hard to obtain in a conventional manner, can be acquired, the new information including information that pertains to a compound or the like indicating a change in amount according to the severity of cancer among compounds indicating a distribution similar to that of the specific compound on the fluorescent image.
Inventors:
Shinichi Yamaguchi
Application Number:
JP2019568538A
Publication Date:
July 21, 2021
Filing Date:
February 05, 2018
Export Citation:
Assignee:
SHIMADZU CORPORATION
International Classes:
G01N27/62
Domestic Patent References:
| JP2017224283A |
Foreign References:
| WO2017002226A1 | ||||
| WO2014175211A1 |
Other References:
新間秀一,イメージング質量顕微鏡を用いたがんの不均一性の解析,実験医学,2018年 2月 1日,36/2,211-217
Attorney, Agent or Firm:
Kyoto International Patent Office