Title:
新規多重特異的結合タンパク質
Document Type and Number:
Japanese Patent JP6919100
Kind Code:
B2
Abstract:
The present disclosure relates to a novel multi-specific binding protein, specifically, a novel multi-specific binding protein prepared by supplementing drawbacks of various conventionally disclosed multi-specific binding proteins, for example, a bispecific binding protein, more specifically, a novel multi-specific binding protein including a polypeptide, wherein heavy chain CH1 domain and CL domain of a antibody constant region are not included but a heavy chain variable region and/or a light chain variable region are consecutively linked in the polypeptide.
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Inventors:
Jean Sail
Park Young Woo
Park Bunchang
Song Jae Ho
Park Young Woo
Park Bunchang
Song Jae Ho
Application Number:
JP2019566550A
Publication Date:
August 25, 2021
Filing Date:
April 18, 2017
Export Citation:
Assignee:
Y-BIOLOGICS INC.
International Classes:
C07K16/46
Other References:
Jakob, C. G. et al.,"Structure reveals function of the dual variable domain immunoglobulin (DVD-IgTM) molecule",MAbs,2013年,Vol. 5,pp. 358-363
Kontermann, R. E.,"Dual targeting strategies with bispecific antibodies",MAbs,2012年,Vol. 4,pp. 182-197
Zhao, J.-X. et al.,"Stabilization of the single-chain fragment variable by an interdomain disulfide bond and its effect on antibody affinity",Int. J. Mol. Sci.,2011年,Vol. 12,pp. 1-11
Kontermann, R. E.,"Dual targeting strategies with bispecific antibodies",MAbs,2012年,Vol. 4,pp. 182-197
Zhao, J.-X. et al.,"Stabilization of the single-chain fragment variable by an interdomain disulfide bond and its effect on antibody affinity",Int. J. Mol. Sci.,2011年,Vol. 12,pp. 1-11
Attorney, Agent or Firm:
Kenjiro Yamaguchi
Hironori Nagayama
Kenichi Morita
Hironori Nagayama
Kenichi Morita