Title:
炎症を処置するための化合物および方法
Document Type and Number:
Japanese Patent JP6924211
Kind Code:
B2
Abstract:
The present disclosure relates to, among other things, compositions and methods for treating an inflammatory condition including, but not limited to, ocular inflammation, dry eye disease, and ocular neuropathic pain. One aspect of the present disclosure relates to a composition comprising (a) chemerin or a fragment or analog thereof and (b) a lipid entity linked to the chemerin or fragment or analog thereof.
Inventors:
Cohen, charles
Kumar, Krishna
Copin, Alain S.
Harwood, Benjamin N.
Raman, Benkata S.
Hamler, pedrum
Kumar, Krishna
Copin, Alain S.
Harwood, Benjamin N.
Raman, Benkata S.
Hamler, pedrum
Application Number:
JP2018557295A
Publication Date:
August 25, 2021
Filing Date:
January 23, 2017
Export Citation:
Assignee:
TUFTS MEDICAL CENTER,INC.
TRUSTEES OF TUFTS COLLEGE
On Target Therapeutics, LRC
TRUSTEES OF TUFTS COLLEGE
On Target Therapeutics, LRC
International Classes:
A61K38/19; A61K47/54; A61P27/02
Foreign References:
| WO2014168721A1 |
Other References:
Doyle, J.R. et al.,Development of a membrane-anchored chemerin receptor agonist as a novel modulator of allergic airway inflammation and neuropathic pain,The Journal of Biological Chemistry,2014年 5月 9日,Vol.289, No.19,p.13385-13396,doi:10.1074/jbc.M113.522680
Cash, J.L. et al.,Resolution of inflammation: targeting GPCRs that interact with lipids and peptides,Drug Discovery Today,2014年 8月,Vol.19, No.8,p.1186-1192,doi:10.1016/j.drudis.2014.06.023
Herova, M. et al.,ChemR23, the receptor for chemerin and resolvin E1, is expressed and functional on M1 but not on M2 macrophages,The Journal of Immunology,2015年,Vol.194, No.5,p.2330-2337,doi:10.4049/jimmunol.1402166
遠藤平仁,炎症収束因子―自然免疫から獲得免疫への橋梁―,日本臨床免疫学会会誌,2013年,第36巻,第3号,p.156-161
Cash, J.L. et al.,Resolution of inflammation: targeting GPCRs that interact with lipids and peptides,Drug Discovery Today,2014年 8月,Vol.19, No.8,p.1186-1192,doi:10.1016/j.drudis.2014.06.023
Herova, M. et al.,ChemR23, the receptor for chemerin and resolvin E1, is expressed and functional on M1 but not on M2 macrophages,The Journal of Immunology,2015年,Vol.194, No.5,p.2330-2337,doi:10.4049/jimmunol.1402166
遠藤平仁,炎症収束因子―自然免疫から獲得免疫への橋梁―,日本臨床免疫学会会誌,2013年,第36巻,第3号,p.156-161
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Natsuki Morishita