Title:
ペグ化ＩＬ−１１の組成物および方法
Document Type and Number:
Japanese Patent JP6937984
Kind Code:
B2
Abstract:
Methods are provided for producing a PEGylated interleukin 11 (IL-11) by treating a recombinant IL-11 PEGylated with an equimolar to low molar excess of PEG carrying an amine-reactive group to achieve a highly pure monoconjugate preparation, which provides improved half-life in serum while having desirable therapeutic activity and presenting fewer side-effects. Most preferably, the IL-11 is an N-terminally truncated human or humanized IL-11 and has a 20 Kd or 40 Kd branched PEG moiety, Y- or comb-shaped in particular, coupled to the N-terminal amino group. Such compounds are characterized by substantially increased stability in serum and sustained biological activity while exhibiting significantly reduced plasma expansion.
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Inventors:
You, Qu-Min
Choo, Qui-rim
Fock manson
Lau, Johnson, Innum
Choo, Qui-rim
Fock manson
Lau, Johnson, Innum
Application Number:
JP2017565038A
Publication Date:
September 22, 2021
Filing Date:
March 01, 2016
Export Citation:
Assignee:
NANSHA BIOLOGICS (HONG KONG) LIMITED
International Classes:
C07K14/54; A61K9/19; A61K38/20; A61K39/395; A61K45/00; A61K47/60; A61P1/00; A61P5/38; A61P7/00; A61P9/00; A61P11/00; A61P19/00; A61P25/04; A61P29/00; A61P43/00
Domestic Patent References:
| JP2012500845A | ||||
| JP2011051991A | ||||
| JP2005281302A |
Foreign References:
| WO2013020079A1 | ||||
| KR1020110051246A | ||||
| US20070111240 |
Attorney, Agent or Firm:
Patent business corporation r&c