Title:
造血器型プロスタグランジンＤシンターゼ阻害剤としての１，３二置換シクロブタンまたはアゼチジン誘導体
Document Type and Number:
Japanese Patent JP6938628
Kind Code:
B2
Abstract:
A compound of formula (I)wherein R, R1, R2, R3, Y, Y1, a, X, and Z are as defined herein.The compounds of the present invention are inhibitors of hematopoietic prostaglandin D synthase (H-PGDS) and can be useful in the treatment of Duchenne Muscular Dystrophy. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting H-PGDS activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.
Inventors:
David, Norman, Deaton
Yu, Guo
Ashley, Paul, Hancock
Christie, Schulte
Barry, George, Shearer
Emily, Despanier, Smith
Eugene, El. Stewart
Stephan, Andrew, Thomson
Yu, Guo
Ashley, Paul, Hancock
Christie, Schulte
Barry, George, Shearer
Emily, Despanier, Smith
Eugene, El. Stewart
Stephan, Andrew, Thomson
Application Number:
JP2019520150A
Publication Date:
September 22, 2021
Filing Date:
October 12, 2017
Export Citation:
Assignee:
GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED
International Classes:
C07D417/12; A61K31/428; A61P1/04; A61P1/18; A61P9/10; A61P11/00; A61P11/02; A61P11/06; A61P17/00; A61P17/02; A61P17/06; A61P19/02; A61P21/00; A61P21/04; A61P29/00; A61P35/00; A61P37/06; A61P37/08; A61P43/00
Domestic Patent References:
| JP2009510170A | ||||
| JP2002501047A | ||||
| JP2007522233A |
Foreign References:
| US20030078420 | ||||
| WO2010024903A1 |
Attorney, Agent or Firm:
Hiroyuki Nagai
Yukitaka Nakamura
Satoru Asakura
Hiroyuki Fujii
Suzuki Keiyasu
Yukitaka Nakamura
Satoru Asakura
Hiroyuki Fujii
Suzuki Keiyasu