Title:
腫瘍溶解性アデノウイルスによる脳癌の処置方法
Document Type and Number:
Japanese Patent JP6956159
Kind Code:
B2
Abstract:
The present disclosure involves compositions and methods for treating brain cancers having mutations in the retinoblastoma (Rb) pathway using an oncolytic adenovirus comprising an alteration in the Rb binding site of E1A, and a targeting motif inserted in the Ad fiber protein. The adenovirus is able to kill the tumor cells without harming cells with a wild-type retinoblastoma pathway.
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Inventors:
Huejo Juan
Manzano-Gomez Candelleria
Conrad Charles
Lang Fred
Young W. Kay. Alfred
Toufaro frank
Manzano-Gomez Candelleria
Conrad Charles
Lang Fred
Young W. Kay. Alfred
Toufaro frank
Application Number:
JP2019199677A
Publication Date:
October 27, 2021
Filing Date:
November 01, 2019
Export Citation:
Assignee:
DN NATRICS INC.
International Classes:
A61K35/761; A61K31/165; A61K31/196; A61K31/337; A61K31/4155; A61K31/475; A61K31/513; A61K31/519; A61K31/704; A61K33/243; A61K38/04; A61K45/00; A61K48/00; A61K51/00; A61P25/00; A61P35/00; A61P43/00
Foreign References:
| US20030138405 |
Other References:
Molecular Therapy,2008年03月16日,Vol.16, No.3,p.487-493
Can oncolytic adenovirus be implemented as therapeutic strategies for DIPGs?,DIPG European Meeting,2012年02月23日,www.cristianriverfoundation.org/media/DIPGworkshopsmedia/202 - SPAIN - Oncolytic Adenovirus (Alonso)
Can oncolytic adenovirus be implemented as therapeutic strategies for DIPGs?,DIPG European Meeting,2012年02月23日,www.cristianriverfoundation.org/media/DIPGworkshopsmedia/202 - SPAIN - Oncolytic Adenovirus (Alonso)
Attorney, Agent or Firm:
Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Kazuya Kawamoto