Title:
癌治療のための副次的遺伝子不活性化バイオマーカーおよび標的
Document Type and Number:
Japanese Patent JP7193296
Kind Code:
B2
Abstract:
Methods for treating a subject determined to have a cancer comprising a heterozygous inactivation of a housekeeping gene (or a homozygous deletion of a functionally redundant housekeeping gene) by treating the subject with an inhibitor of the gene. For example, a subject having a cancer with an ENO gene deletion can be treated with a glycolysis inhibitor, such as an enolase inhibitor. In some aspects, a subject having a cancer with an ARS gene deletion can be treated with an ARS inhibitor.
Inventors:
Florian El. Müller
Elliott Fletcher-Sananicorn
Simona Cora
Elisa Akhilanti
Ronald Depinho
Elliott Fletcher-Sananicorn
Simona Cora
Elisa Akhilanti
Ronald Depinho
Application Number:
JP2018192504A
Publication Date:
December 20, 2022
Filing Date:
October 11, 2018
Export Citation:
Assignee:
BOARD OF REGENTS,THE UNIVERSITY OF TEXAS SYSTEM
International Classes:
A61K39/395; A61K31/7088; A61K45/00; A61K48/00; A61P35/00; C12Q1/6886; G01N33/50
Foreign References:
| US20020127714 |
Other References:
Nature Reviews Cancer,2005年,Vol.5,p.689-698
Molecular Biology of the Cell,2003年,Vol.14,p.2201-2205
Molecular Biology of the Cell,2003年,Vol.14,p.2201-2205
Attorney, Agent or Firm:
Shusaku Yamamoto
Morishita Natsuki
Morishita Natsuki