Title:
安定化抗微生物性ペプチド
Document Type and Number:
Japanese Patent JP7360419
Kind Code:
B2
Abstract:
The present invention provides methods of designing and making structurally stabilized anti-microbial peptides for the prophylaxis and treatment of infection. Methods are also disclosed for designing stabilized anti-microbial peptides that are selectively lytic/cytotoxic to bacteria, allowing for internal use of anti-microbial peptides without mammalian membrane disruption and cytotoxicity.
More Like This:
Inventors:
Loren Di Warrensky
Lida Motorda
Gregory H. Bird
Lida Motorda
Gregory H. Bird
Application Number:
JP2021091780A
Publication Date:
October 12, 2023
Filing Date:
May 31, 2021
Export Citation:
Assignee:
Dana Farber Cancer Institute, Incorporated
International Classes:
C07K14/46; A61K38/17; A61P31/04
Other References:
Hubert Chapuis et al.,Effect of hydrocarbon stapling on the properties of α-helical antimicrobial peptides isolated from the venom of hymenoptera,Amino Acids,2012年04月17日,Vol.43, No.5,p.2047-2058,doi: 10.1007/s00726-012-1283-1
Christopher J. Arnusch et al.,Enhanced membrane pore formation through high-affinity targeted antimicrobial peptides,PLoS One,2012年06月29日,Vol.7, Issue 6,e39768,doi: 10.1371/journal.pone.0039768
Tzu-Lin Sun et al.,Membrane permeability of hydrocarbon-cross-linked peptides,Biophys. J.,2013年05月07日,Vol.104, No.9,p.1923-1932,doi: 10.1016/j.bpj.2013.03.039
Christopher J. Arnusch et al.,Enhanced membrane pore formation through high-affinity targeted antimicrobial peptides,PLoS One,2012年06月29日,Vol.7, Issue 6,e39768,doi: 10.1371/journal.pone.0039768
Tzu-Lin Sun et al.,Membrane permeability of hydrocarbon-cross-linked peptides,Biophys. J.,2013年05月07日,Vol.104, No.9,p.1923-1932,doi: 10.1016/j.bpj.2013.03.039
Attorney, Agent or Firm:
Michiko Matsutani
Yasushi Ochiai
Yasushi Ochiai