Title:
サンプルを画像化およびアブレーションするためのシステムおよび方法
Document Type and Number:
Japanese Patent JP7429256
Kind Code:
B2
Abstract:
Disclosed herein are systems for imaging and ablating a sample. An imaging/ablating device includes an optical assembly, a sample stage, and a receiver. The optical assembly enables ablation of a region of interest within the sample. The laser light propagated from the optical assembly during ablation propagates substantially in the same direction as the direction of travel of the ablation plume toward the receiver. A laser focus detection unit including at least one reference laser and photodetector generates at least one real-time detection signal indicative of one or more characteristics of the sample during ablation and/or of a distance from the objective to the sample stage or a surface of the sample. A controller coupled with the laser focus detection unit dynamically controls in real-time one or more parameters of the ablation laser and/or a position of the objective and/or a position of the receiver relative to the sample to improve MS imaging quality.
Inventors:
Alexander A. Makarov
Michael Dennis Ward
Reiner Daum
Michael Dennis Ward
Reiner Daum
Application Number:
JP2022085925A
Publication Date:
February 07, 2024
Filing Date:
May 26, 2022
Export Citation:
Assignee:
FAE Deutschland Gesellschaft Mitt Beschlenktel Hafzung
Thermo Fisher Scientific (Bremen) Gamem Beher
Life Technologies Corporation
Thermo Fisher Scientific (Bremen) Gamem Beher
Life Technologies Corporation
International Classes:
G02B21/00; G01N1/00; G01N1/22; G01N21/64; G01N27/62; G02B21/26; G02B21/36; H01J49/00; H01J49/04; H01J49/26
Domestic Patent References:
| JP2017097301A | ||||
| JP2012159854A | ||||
| JP2021028072A | ||||
| JP2002321080A | ||||
| JP6265773A |
Foreign References:
| US5208451 | ||||
| WO2019246033A1 |
Attorney, Agent or Firm:
Shinichiro Tanaka
▲吉▼田 和彦
Hiroyuki Suda
Ichiro Kurasawa
Yasushi Yamamoto
Hiroko Suzuki
Makoto Watanabe
▲吉▼田 和彦
Hiroyuki Suda
Ichiro Kurasawa
Yasushi Yamamoto
Hiroko Suzuki
Makoto Watanabe