Title:
ビタミンカチオン性脂質
Document Type and Number:
Japanese Patent JP7441802
Kind Code:
B2
Abstract:
Disclosed are cationic lipids comprising a vitamin substructure and an ionizable nitrogen-containing group. Cationic lipids provided herein can be useful for delivery and expression of mRNA and encoded protein, e.g., as a component of liposomal delivery vehicle, and accordingly can be useful for treating various diseases, disorders and conditions, such as those associated with deficiency of one or more proteins.
Inventors:
Jean, E
Curve, Shrilang
Karma Cal, Saswata
Delosa, Frank
Hartrain, Michael
Curve, Shrilang
Karma Cal, Saswata
Delosa, Frank
Hartrain, Michael
Application Number:
JP2020566716A
Publication Date:
March 01, 2024
Filing Date:
May 29, 2019
Export Citation:
Assignee:
Translate Bio, Incorporated
International Classes:
A61K48/00; A61K9/12; A61K9/127; A61K9/72; A61K39/00; A61K47/18; A61K47/20; A61P1/16; A61P11/00; A61P31/00; A61P37/04; A61P43/00; C12N15/12; C12N15/33; C12N15/37; C12N15/38; C12N15/40; C12N15/44; C12N15/45; C12N15/46; C12N15/47; C12N15/49; C12N15/51; C12N15/54; C12N15/89
Domestic Patent References:
| JP2015501309A | ||||
| JP2013533224A |
Foreign References:
| WO2013073480A1 |
Other References:
Chemistry and Physics of Lipids,2014年,Vol.183,pp.117-136
Molecules,2012年,Vol.17,pp.1138-1148
Bioorg. Med. Chem. Lett.,2000年,Vol.10,pp.787-791
Molecules,2012年,Vol.17,pp.1138-1148
Bioorg. Med. Chem. Lett.,2000年,Vol.10,pp.787-791
Attorney, Agent or Firm:
Shusaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto