Title:
粉末経鼻投与製剤
Document Type and Number:
Japanese Patent JP7470221
Kind Code:
B2
Abstract:
A powder preparation for nasal administration containing a particulate of steroid hormones having an average particle size of 50 to 300 µm as an active ingredient is prepared. The powder preparation for nasal administration may further contain a water-soluble polymer (particularly, water-soluble polysaccharides such as a cellulose having a hydroxyalkyl group). The particulate of steroid hormones may be testosterone and/or a derivative thereof. The water-soluble polymer may be in a particulate form. The ratio of the water-soluble polymer may be about 1 to 50 parts by weight relative to 1 part by weight of the particulate of steroid hormones. The powder preparation for nasal administration may be a powder preparation for nasal administration which can control a Cmaxof steroid hormones to not more than 15 ng/ml. A powder preparation for nasal administration which can control a plasma concentration of steroid hormones such as testosterone in a specific range for a long period of time is provided.
Inventors:
Koichi Minato
Tomoya Fujisawa
Kenji Shimizu
Norihisa Saito
Hiroya Yajima
Kazuhiro Sasaki
Tomoya Fujisawa
Kenji Shimizu
Norihisa Saito
Hiroya Yajima
Kazuhiro Sasaki
Application Number:
JP2023015215A
Publication Date:
April 17, 2024
Filing Date:
February 03, 2023
Export Citation:
Assignee:
ASKA Pharmaceutical Co., Ltd.
International Classes:
A61K31/568; A61K9/14; A61K47/36; A61K47/38; A61P15/08
Domestic Patent References:
| JP2007001926A | ||||
| JP9291026A | ||||
| JP2014506935A | ||||
| JP2007530446A |
Other References:
ASCENTIIS, Alessia De et al.,Delivery of Nasal Powders of beta-Cyclodextrin by Insufflation,Pharmaceutical Research,1996年,Vol. 13, No. 5,p. 734-738,ISSN: 1573-904X
Attorney, Agent or Firm:
Hiroshi Sakanaka
Mitsuo Kuwata
Mitsuo Kuwata