Document Type and Number:
Japanese Patent JPH0129800
Kind Code:
B2
Abstract:
A novel process for the preparation of a conjugate of a 21-hydroxy steroid and a nucleoside-5'-monophosphate comprises reacting the 21-hydroxy steroid with a derivative of the nucleoside-5'-monophosphate (in which hydroxy groups on the carbohydrate ring are protected) in the presence of 2,4,6-triisopropylbenzene sulphonyl chloride (TPS) as a condensing agent under anhydrous conditions and removing the hydroxy protecting groups from the conjugate thereby obtained. Such conjugates and their salts are useful as anticancer and antiviral agents.
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Inventors:
CHAN IRU HON
Application Number:
JP27585285A
Publication Date:
June 14, 1989
Filing Date:
December 07, 1985
Export Citation:
Assignee:
HONEI SEIYAKU KK
International Classes:
C07H19/16; A61K31/70; A61K31/704; A61K31/7042; A61K31/7052; A61K31/706; A61K31/7064; A61K31/7072; A61K31/7076; A61P31/12; A61P35/00; C07H19/10; C07H19/12; C07H19/14; C07H19/20; C07H19/207; C07J43/00; C07J51/00
Next Patent: JPH0129801