Japanese Patent JPH0132240

B2

The present invention relates to carboxyalkyl dipeptides which are inhibitors of angiotensin-converting enzyme and are useful as antihypertensive agents and in the treatment of congestive heart failure. The compounds of the present invention are compounds of the formulae I and II and the pharmaceutically acceptable salts thereof, wherein R and R6 are the same or different and are hydroxy or lower alkoxy; R1 is benzyloxylower alkyl or benzylthiolower alkyl; R2 is benzylthiomethyl, 2-phenylethylthiomethyl, naphthylmethylthiomethyl, methylbenzylthiomethyl; 2-(carboxyphenyl)ethyl or 2-(alkoxycarbonylphenyl)ethyl; and R3 is hydrogen, lower alkyl or aminolower alkyl.

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BAANAADO AARU NUUSUTATSUDO
ERYA ETSUCHI GOORUDO
ERIZABESU EMU SUMISU

JP16851181A

June 29, 1989

October 21, 1981

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SCHERING PLOUGH CORP

C07D209/44; A61K38/00; A61K38/55; A61P9/12; C07D209/52; C07D215/48; C07D225/02; C07D267/22; C07D339/08; C07D491/048; C07D491/052; C07D491/113; C07D495/10; C07K1/113; C07K5/02; C07K5/06; C07K14/81; C12N9/99

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