Title:
【発明の名称】免疫調節組成物及びそれらの使用
Document Type and Number:
Japanese Patent JPH01500595
Kind Code:
A
Abstract:
Novel methods or compositions are provided for modulating the immune system, so as to be able to selectively stimulate or inactivate lymphocytes in relation to a particular transplantation antigen context. Particularly, mixtures may be employed associated with the more common transplantation antigens of a host population. In this manner, a large number of people can be treated, for example, by immunization, stimulation of particular T-cells or B-cells in relation to a pathogenic invasion or other aberrant state, e.g. neoplasia, treatment of autoimmune diseases, and the like. Particularly, the compositions may involve an oligopeptide involving as a first region a consensus sequence and an epitope or the first region may be joined to a second region comprising an antibody target sequence which is capable of competing with an epitopic site of an antigen of interest.
Inventors:
Gefter, Markham El.
Gillette, Jean-Gerrard
Gillette, Jean-Gerrard
Application Number:
JP50447687A
Publication Date:
March 01, 1989
Filing Date:
June 26, 1987
Export Citation:
Assignee:
MASSACHUSETTS INSTITUTE OF TECHNOLOGY
International Classes:
A61K39/00; A61K39/015; A61K39/02; A61K39/12; A61K45/00; A61K38/00; A61P37/00; C07K14/705; C07K19/00; (IPC1-7): A61K45/05; A61K39/12; A61K39/02; A61K39/015; A61K39/00
Foreign References:
| US4478823A | 1984-10-23 |
Attorney, Agent or Firm:
Aoki Akira (3 outside)