Document Type and Number:
Japanese Patent JPH01502906
Kind Code:
A
Abstract:
PCT No. PCT/GB87/00253 Sec. 371 Date Nov. 23, 1988 Sec. 102(e) Date Nov. 23, 1988 PCT Filed Apr. 15, 1987 PCT Pub. No. WO87/06227 PCT Pub. Date Oct. 22, 1987.Indoloquinone compounds useful as cytostatic agents have formula (I), where R2 and R3 are in each case, hydrogen, halogen, an alkyl group (which may be substituted), an alkoxy group or an aryloxy group, an alkylthio group or an arylthio group, a primary or secondary amino group, hydroxy group or an amino group; R5 is hydrogen, a hydroxy group, an alkoxy group, an alkyl group (which may be substituted), or a carbohydrate moiety; R6 and R7 are in each case hydrogen, halogen, or an alkyl group; R8 is a group -CH2X1, a group -CO2-M+, where M+ is a metal ion; a group -CO2R10, where R10 is hydrogen or an alkyl group (which may be substituted); a group -CONR'R'', where R' and R'' are hydrogen or alkyl groups (which may be substituted); R9 is a group -CR11R12X2, a group -CO2-M+, where M+ is a metal ion; a group -CO2R13, where R11, R12 and R13 are in each case hydrogen or an alkyl group (which may be substituted); a group -CONR'R'', where R' and R'' are in each case hydrogen or an alkyl group (which may be substituted), and X1 and X2 (when present) are hydrogen, or groups selected from OH, OR, -OC=OR, -OCO2R, -OC=ONRR, SH, SR, -SC=OR, -SC=SR, -SCO2R, -SC=SOR, -SC-ONRR, -SC-SNRR, and -NRR [where R is hydrogen, an alkyl group (which by be substituted), or an aryl group (which may be substituted)], -OSOR, -OSO2R and OP(OR)2 [where R is hydrogen, an alkyl group (which may be substituted,), an aryl group (which may be substituted), or a carbohydrate moiety]; and X1 and X2 may be the same or different. Preferred compounds and methods for their manufacture are provided.
Application Number:
JP50232487A
Publication Date:
October 05, 1989
Filing Date:
April 15, 1987
Export Citation:
International Classes:
A61K31/40; A61K31/403; A61K31/404; A61K31/44; A61K31/4427; A61K31/445; A61K31/535; A61P35/00; C07D209/12; C07D209/14; C07D209/00; C07D209/18; C07D209/42; C07D401/00; C07D401/04; C07D401/06; C07D401/12; C07D403/00; C07D403/04; C07D403/06; C07D413/06; (IPC1-7): C07D403/04; C07D401/12; C07D401/04; C07D209/42; C07D209/14; C07D209/12; A61K31/535; A61K31/445; A61K31/44; A61K31/40