Document Type and Number:
Japanese Patent JPH0154348
Kind Code:
B2
Abstract:
An epoxysuccinic acid derivative of the formula wherein R1 is hydrogen, alkali metal, alkyl having 1-2 carbon atoms, cycloalkyl having 5-6 carbon atoms or benzyl, R2 is alkyl having 3-4 carbon atoms or benzyl, R3 is hydrogen or methyl, and R4 is alkyl having 1-10 carbon atoms, phenyl, benzyl, phenethyl, cycloalkyl having 3-6 carbon atoms or a group of the formula wherein R5 is hydrogen, alkyl having 1-4 carbon atoms or said alkyl substituted with hydroxy, methylmercapto, phenyl, hydroxyphenyl, indolyl, an optionally protected carboxy, an optionally protected amino or an optionally protected guanidino, and R6 is hydroxy, alkalimetaloxy, alkoxy having 1-2 carbon atoms, benzyloxy, amino or dimethylamino, or R3 and R4 taken together with the nitrogen atom to which they are attached form a 5-6 membered heterocyclic ring, or said heterocyclic ring substituted with a protected carboxy.
Inventors:
TAMAI MASAHARU
ADACHI TAKASHI
MORIMOTO SHIGEO
OGUMA SEIJI
HANADA KAZUNORI
OOMURA SADAFUMI
ADACHI TAKASHI
MORIMOTO SHIGEO
OGUMA SEIJI
HANADA KAZUNORI
OOMURA SADAFUMI
Application Number:
JP2236579A
Publication Date:
November 17, 1989
Filing Date:
February 27, 1979
Export Citation:
Assignee:
TAISHO PHARMA CO LTD
International Classes:
C07D303/48; A61K31/335; A61K31/336; A61P43/00; C07K5/06; C07K5/062; C07K5/065; C07K14/81; A61K38/00
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