Japanese Patent JPH0214329

B2

15-oxygenated sterols, having the ability to inhibit the biosynthesis of mevalonic acid, and produce other effects derived from their ability to inhibit the biosynthesis of mevalonic acid, are disclosed. The 15-oxygenated sterols correspond to the structural formula: where: R1 is -OH, =O, -OR4, a sulfate group, or a Mg, Na, or K salt of a sulfate group; R2 is -OH, =O, or R3 is alpha H, beta H, or an alpha C1 to C6 alkyl group; Rr is a C1 to C6 alkyl group and preferably a C1 to C3 alkyl group; R5 is a C1 to C20 aliphatic group, a substituted C1 to C20 aliphatic group, or a phenyl group; and n is a whole number from 2 to 6 and preferably from 2 to 4. The basic ring structure may be saturated or unsaturated, and when it is possible for the R1 and R2 substituents to be in more than one steric position, they may be in either the alpha or beta position. It is of course understood that the basic sterol structure may contain substituents that do not adversely effect the properties of the compound at positions other than those of R1, R2, and R3.

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JOOJI JON SUKUROEPUFUAA JUNIA
EDOWAADO JEIMUSU PARISHU
ANDORYUU OGASUTO KANDATSUCHI

JP5816378A

April 06, 1990

May 16, 1978

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JOOJI JON SUKUROEPUFUAA JUNIA
EDOWAADO JEIMUSU PARISHU
ANDORYUU OGASUTO KANDATSUCHI

A61K31/575; A61P3/00; A61P3/04; A61P3/06; A61P43/00; C07J9/00; C07J43/00; C07J51/00

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