Japanese Patent JPH0220620

B2

NEW MATERIAL:A carbaprostacyclin of formulaI(R<1> is H, hydroxyl-protecting group; R<2> is alkyl, alkenyl, alkinyl, hydroxy-substituted alkyl, alkoxy-substituted alkyl, alkinyl-substituted cycloalkyl; R3 is H, alkyl; A is ethylene, trans-vinylene, ethynilene; n is 1-8). EXAMPLE:5alpha-Hydroxy-6beta-carboxy-6beta, 9alpha-methylene-11alpha, 15alpha-ditetrahydropyranyloxyprost-13-(E)-enic aicd. USE:An intermediate for enhancing platelet factor having a strong effect. PREPARATION:A novel compound of formula II is treated with a base to give a compound of formulaIwhere R<3> is H. Further, the compound of formula II is treated with p-toluenesulfonic acid in benzene to be converted into its lactone, which is made to react with an alcohol in the presence of alkali carbonate to give a compound of formulaIwhere R<3> is alkyl.

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AMAMYA SHIGEO
KOJIMA KOICHI
SAKAI KYOSHI

JP21169181A

May 10, 1990

December 25, 1981

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SANKYO CO

C07C69/675; A61K31/20; A61K31/215; A61K31/35; A61P7/02; C07C51/00; C07C62/06; C07C62/08; C07C62/30; C07C67/00; C07C69/708; C07C69/73; C07D309/12; C07F7/18

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