Document Type and Number:
Japanese Patent JPH0234346
Kind Code:
B2
Abstract:
PURPOSE:To readily and efficiently obtain chanoclavine or isochanoclavine useful as medicines and intermediates therefor having an ergot alkaloid skeletal structure, by reducing a novel carbamate derivative corresponding to the aimed compound with a reducing agent. CONSTITUTION:A novel substance expressed by formula II (either one of R<1> and R<2> is CH2OH and the other is H) is reduced with a reducing agent, for example lithium aluminum hydride, etc., to readily obtain the aimed compound expressed by formula II in 85-95% yield. The compound is useful not only as an intermediate for easy and short-step production of ergot alkaloids, especially clavine type alkaloids, useful for medicines having a prolactin secretion- suppressive action, uterine contractive action, etc., but also as a medicine since it has individual alpha-receptor-blocking action, anti-serotonin action, etc., similar those of the above-mentioned medicine. The novel substance expressed by formula I is prepared from a compound expressed by formula III through compounds expressed by formulas IV, V, etc. in 6 steps.
Inventors:
SOMEI MASANORI
Application Number:
JP20388985A
Publication Date:
August 02, 1990
Filing Date:
September 13, 1985
Export Citation:
Assignee:
KISSEI PHARMACEUTICAL
International Classes:
C07D457/00; A61K31/40; A61K31/403; A61K31/404; A61P9/12; A61P25/02; A61P25/04; A61P43/00; C07D209/10; C07D209/12; C07D209/90
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