Document Type and Number:
Japanese Patent JPH026360
Kind Code:
B2
Abstract:
The invention relates to novel bisquaternary ammonium derivatives of 2 beta ,16 beta -dipiperidino-5 alpha -androstanes having the formula: wherein R2=CH3, C2H5 or CH2CH=CH2; R3=CH3, C2H5 or CH2CH=CH2, with the proviso that R2 and R3 are not CH3 simultaneously; R4=O or H( beta OR5), wherein R5=H or aliphatic carbacyl (1-6 C); and X=a halogen atom, to processes for their preparation and to pharmaceutical preparations. The invention also relates to novel 16-monoquaternary analogs as intermediates. The compounds possess neuromuscular blocking activity.
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Inventors:
KORUDAA YAN
Application Number:
JP50015881A
Publication Date:
February 08, 1990
Filing Date:
December 09, 1980
Export Citation:
Assignee:
AKZO NV
International Classes:
A61K31/58; A61P25/02; C07J43/00