【発明の名称】アミンのアリールオキシ‐、アリールチオ‐、ヘテロアリールオキシ‐、ヘテロアリールチオ‐アルケニレン誘導体

Japanese Patent JPH03501862

A

Aryloxy- and heteroaryloxy-alkylene derivatives of amines of formula wherein each of A and B is a group of formula (i) to (iii): wherein Y is -O-, -S- or -NR- in which R is hydrogen or C1-C6 alkyl; each of R3, R4, R5 and R6 is independently: a) hydrogen, halogen, hydroxy, cyano or nitro; b) C1-C6 alkyl unsubstituted or substituted by halogen, c) C1-C6 alkoxy or C1-C6 alkylthio; d) C1-C6 alkyl-sulfonyl; e) a substituted amine group -NR7R8; f) a -COR12 group; or g) two adjacent groups of R3, R4, R5 and R6, taken together, form a C1-C4 alkylenedioxy group; each of R1 and R2 independently is hydrogen, C3-C6 alkynyl, C3-C6 alkenyl or C1-C6 alkyl unsubstituted or substituted by phenyl; or R1 and R2 taken together with the nitrogen atom to which they are linked, form a substituted or unsubstituted, saturated heterocyclic ring; and the pharmaceutically acceptable salts thereof; are active on the central nervous nervous system, in particular as antidepresssant, antiobesity antismoking and anti-alcoholabuse agents.

Meloni, clown
Dostail, Philip
Detura Torre, Arturo
Bonsignori, Alberto

JP51149089A

April 25, 1991

October 02, 1989

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Faria Talia Carlo Erba Etsuse Elle Elle

A61K31/135; A61K31/357; A61K31/36; A61K31/38; A61K31/381; A61K31/40; A61P3/04; A61P25/24; A61P25/26; A61P25/30; C07C47/232; C07C47/24; C07C47/277; C07C217/46; A61K31/13; C07C217/48; C07C217/54; C07C217/72; C07C217/84; C07C255/54; C07C275/10; C07C275/32; C07C317/22; C07D207/335; C07D317/54; C07D317/58; C07D317/64; C07D333/20; C07D333/32; C07D521/00; (IPC1-7): A61K31/13; A61K31/36; A61K31/38; A61K31/40; C07C47/277; C07C217/48; C07C255/54; C07C275/32; C07D207/335; C07D317/58; C07D333/20; C07D333/32; C07D521/00

Yoshio Kawaguchi (2 outside)

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