Title:
【発明の名称】ドーパミン‐β‐ヒドロキシラーゼ抑制剤
Document Type and Number:
Japanese Patent JPH03501972
Kind Code:
A
Abstract:
Compounds of formula (I) and pharmaceutically acceptable salts or hydrates thereof are described in which, X is H, F, Cl, Br, I, C1-4alkyl, CN, NO2, SO2NH2, COOH, OH, CHO, C1-4alkoxy, CH2OH, CH2OC1-4alkyl, CF3, C2F5, C3F7, SO2CH3, SO2CF3, or CO2CaH2a+1 wherein a is 1 to 5, or any accessible combination thereof up to 5 substituents; n is 0 to 5; m is 1 to 5; R is H or C1-4alkyl. These compounds are dopamine- beta -hydroxylase inhibitors. Pharmaceutical compositions are described as are methods of use. Processes for the preparation of these compounds are described.
Inventors:
Cruz, Lawrence Ivan
Ross, Stefan Tray
Elliott Howard, Allstein
Ross, Stefan Tray
Elliott Howard, Allstein
Application Number:
JP50135889A
Publication Date:
May 09, 1991
Filing Date:
December 21, 1988
Export Citation:
Assignee:
SmithKline Beckman Corporation
International Classes:
A61K31/415; A61P9/12; A61P43/00; C12N9/99; C07D233/84; (IPC1-7): C07D233/84; A61K31/415
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)