Title:
【発明の名称】混合ミセル水溶液の製法
Document Type and Number:
Japanese Patent JPH03503899
Kind Code:
A
Abstract:
A process for producing aqueous mixed micelle solutions containing mixed micelles formed from lipoids and salts of bile acids, in which, if desired, active substances hardly soluble or insoluble in water are solubilized, is characterized in that the free bile acids are suspended in an aqueous solution possibly containing isotonizing additives and/or water-soluble active substances at a temperature of 40C to 100C, the lipoids are dispersed in this suspension at a temperature of 40C to 100C and the dispersion obtained is neutralized with bases at a temperature of 0C to 100C, provided that, if necessary, the active substances which are hardly soluble or insoluble in water are dispersed together with the lipoids or solubilized in the mixed micelle solution which does not contain these active substances.
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Inventors:
Michael Heinrich
Geritz, Dettreff
Wrestling, georg
Tatsk, Johannes-Wilhelm
Geritz, Dettreff
Wrestling, georg
Tatsk, Johannes-Wilhelm
Application Number:
JP50216490A
Publication Date:
August 29, 1991
Filing Date:
January 16, 1990
Export Citation:
Assignee:
Schering Aktiengesellschaft
International Classes:
A61K9/107; A61K47/28; B01J13/00; A61K; (IPC1-7): A61K9/107; A61K47/28; B01J13/00
Attorney, Agent or Firm:
Toshio Yano (2 outside)