Japanese Patent JPH0443077

B2

Novel 19-nor-steroids of the formula I wherein R1 is an organic group of 1 to 18 carbon atoms optionally containing at least one heteroatom with the atom immediately adjacent the 11-carbon atom being carbon, R2 is a hydrocarbon of 1 to 8 carbon atoms, X is the remainder of a pentagonal or hexagonal ring optionally substituted and optionally containing one unsaturated-bond, the A and B rings are selected from the group consisting of (a) (b) (c) (d) and (e) R' and R'' are individually selected from the group consisting of hydrogen, -CN and alkyl of 1 to 4 carbon atoms with at least one being other than hydrogen, Rx is selected from the group consisting of hydrogen and ORe, Re is selected from the group consisting of hydrogen, optionally substituted alkyl of 1 to 6 carbon atoms and acyl, Ra may be in the E or Z positions as indicated by the wavy line and is selected from the group consisting of and acyloxy, Ra' and Ra'' are alkyl of 1 to 4 carbon atoms or taken together with the nitrogen atom form a heterocycle of 5 to 6 chain members optionally containing another heteroatom with the proviso that when A and B are R1 contains at least one nitrogen, phosphorus or silicium atom and when A and B are R1 is not a linear alkyl and their non-toxic, pharmaceutically acceptable acid addition salts having a remarkable antigluococorticoid activity, their preparation and novel intermediates.

JAN JORUJU TOOCHI
BESUPERUTO TORERI
ROJE DORAE
DANIERU FUIRIBEERU

JP10297983A

July 15, 1992

June 10, 1983

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ROUSSEL UCLAF

A61K31/565; A61K31/585; A61P5/38; C07J1/00; C07J21/00; C07J41/00; C07J43/00; C07J51/00; C07J71/00

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