Title:
【発明の名称】1―アミノメチル―1,2,3,4―テトラヒドロナフタレン
Document Type and Number:
Japanese Patent JPH04500356
Kind Code:
A
Abstract:
The present invention includes compounds represented by the formula: wherein n is 0 or 1; R1, R2, R3, and R4 are independently selected from hydrogen, hydroxy, amino, alkylamino, alkylsulfonylamino, loweralkyl, loweralkoxy, halo, and thioalkoxy; or R1 and R2 or R2 and R3 taken together can form a methylenedioxy or ethylenedioxy bridge; R10 is independently selected from hydrogen, loweralkyl, phenyl, and substituted phenyl; R5 is loweralkyl; R9 is hydrogen or loweralkyl; R6 and R8 are hydrogen; and R7 is wherein m is 0, 1 or 2; X is CH2, O, S or N-CH3; or R7 is wherein s is 0, 1, or 2; Z is C or N; and R11 and R12 are independently selected from hydrogen, halo, hydroxy, methoxy, thiomethoxy, amino and loweralkyl, or R11 and R12 taken together can form a methylenedioxy or ethylenedioxy bridge; or R7 is wherein t is 0 or 1; and R9 taken together form a pyrrolidine ring and then R6 and R8 are hydrogen and R7 is as described above; or R5 and R9 taken together form a pyrrolidine ring and then R6 is hydrogen R7 and R8 taken together may form a phenyl, substituted phenyl, thienyl or furyl ring; or R5 and R8 taken together form a pyrrolidine ring and then R9 and R6 are hydrogen and R7 is phenyl, substituted phenyl, thienyl, or furyl; or R7 and R9 are hydrogen and R6 is benzyl, substituted benzyl, thienylmethyl, or furylmethyl; or a pharmaceutically acceptable salt thereof.
Inventors:
Dayburner Dace, Jiyon Francis
Jill, Robert Edward
Versiya, Juaythema Zeila
Jill, Robert Edward
Versiya, Juaythema Zeila
Application Number:
JP50197389A
Publication Date:
January 23, 1992
Filing Date:
January 13, 1989
Export Citation:
Assignee:
Abbot Laboratories
International Classes:
A61K31/34; A61K31/341; A61K31/357; A61K31/38; A61K31/381; A61K31/44; A61K31/4402; A61K31/4418; A61P9/12; C07C45/00; C07C45/46; C07C45/63; C07C45/71; C07C49/577; C07C49/697; C07C49/747; C07C49/753; C07C62/32; C07C62/34; C07C211/30; C07C215/50; C07C215/58; C07C215/70; C07C217/54; C07C217/74; C07C229/50; C07C233/18; C07C255/47; C07C259/08; C07C311/08; C07C323/22; C07C323/38; C07D207/06; C07D207/08; C07D207/335; C07D213/36; C07D213/38; C07D307/14; C07D307/52; C07D317/70; C07D319/20; C07D319/22; C07D333/20; C07D333/24; C07D405/06; C07D405/12; C07D409/04; C07D409/06; C07D409/12; C07D409/14; C07D207/32; (IPC1-7): A61K31/34; A61K31/38; A61K31/44; C07C215/58; C07C215/70; C07C217/54; C07C255/47; C07C311/08; C07C323/38; C07D213/36; C07D307/14; C07D307/52; C07D319/20; C07D333/20
Attorney, Agent or Firm:
Yoshio Kawaguchi (4 outside)