Title:
【発明の名称】非グリコシル化 ヒト インターロイキン―3 組成物
Document Type and Number:
Japanese Patent JPH04500508
Kind Code:
A
Abstract:
The present invention provides a pharmaceutical composition comprising a recombinant human IL-3 protein analog, rhuIL-3(Asp<15>, Asp<70>) derived by yeast expression and having a biological activity of at least 3.0x10<7> units per milligram in a human bone marrow proliferation assay, and a binding affinity for human monocyte IL-3 receptors, expressed as an inhibition constant, of at least 2.0 x 10<10> M<-1>, and an endotoxin content of less than 1 ng per mg protein.
Inventors:
Anderson, Deek Em
Cosman, david jay
Price, Virginia El
Cosman, david jay
Price, Virginia El
Application Number:
JP50735689A
Publication Date:
January 30, 1992
Filing Date:
June 14, 1989
Export Citation:
Assignee:
IMMUNEX CORPORATION
International Classes:
C12N15/09; A61K38/00; A61K38/17; A61K38/20; A61K39/395; A61P7/00; A61P37/04; C07K14/00; C07K14/52; C07K14/54; C12P21/02; C12R1/865; (IPC1-7): A61K37/02; C07K13/00; C12N15/24; C12P21/02
Attorney, Agent or Firm:
Kyozo Yuasa (4 outside)