Title:
【発明の名称】免疫調節活性を有するマトリックス
Document Type and Number:
Japanese Patent JPH04501714
Kind Code:
A
Abstract:
PCT No. PCT/SE89/00528 Sec. 371 Date May 21, 1991 Sec. 102(e) Date May 21, 1991 PCT Filed Sep. 28, 1989 PCT Pub. No. WO90/03184 PCT Pub. Date Apr. 5, 1990The invention claims an iscom matrix which is not a lipid vesicle comprising at least one lipid and at least one saponim but no intentional antigenic determinants and optionally also adjuvants for use as an immunomodulating agent, medicines, vaccines, kits containing the matrix and new saponins, and a process for preparing the new saponins. The invention also concerns a process for preparing the matrix characterized in that at least one sterol is solubilized in a solvent or detergent, the saponin or saponins are added, the other adjuvants and lipids are optionally also added, whereafter the organic solvent or the detergent may be removed for example with dialysis, ultra filtration, gel filtration or electrophoresis. The sterol and saponin might also be solubilized in the lipids and/or adjuvants.
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Inventors:
Moraine Broll
Robe Glen Karin
Dalsgard Christian
Turin, Yang
Sand quist
Robe Glen Karin
Dalsgard Christian
Turin, Yang
Sand quist
Application Number:
JP51032989A
Publication Date:
March 26, 1992
Filing Date:
September 28, 1989
Export Citation:
Assignee:
Moraine Broll
Robe Glen Karin
Dalsgard Christian
Turin, Yang
Sand quist
Robe Glen Karin
Dalsgard Christian
Turin, Yang
Sand quist
International Classes:
A61K31/565; A61K39/39; A61K45/00; A61K39/00; A61P37/04; C07H3/06; C07H15/256; C07J17/00; C07J63/00; (IPC1-7): C07J63/00; C07J17/00; A61K39/00
Attorney, Agent or Firm:
Akira Asamura (3 outside)