Title:
【発明の名称】制癌化合物
Document Type and Number:
Japanese Patent JPH04502166
Kind Code:
A
Abstract:
PCT No. PCT/GB90/01574 Sec. 371 Date Apr. 10, 1991 Sec. 102(e) Date Apr. 10, 1991 PCT Filed Oct. 12, 1990.Compounds of formula (I) (I) in which R1, R2, R3 and R4 are each separately selected from hydrogen, X, NH-A-NHR and NH-A-N(O)R'R'' wherein X is hydroxy, halogeno, amino, C1-4 alkoxy or C2-8 alkanoyloxy, A is a C2-4 alkylene group with a chain length between NH and NHR or N(O)R'R'' of at least 2 carbon atoms and R, R' and R'' are each separately selected from C1-4 alkyl groups and C2-4 hydroxyalkyl and C2-4 dihydroxyalkyl groups in which the carbon atom attached to the nitrogen atom does not carry a hydroxy group and no carbon atom is substituted by two hydroxy groups, or R' and R'' together are a C2-6 alkylene group which with the nitrogen atom to which R'' and R'' are attached forms a heterocyclic group having 3 to 7 atoms in the ring, but with the proviso that at least one of R1 to R4 is a group NH-A-N(O)R'R'', and physiologically acceptable salts thereof are of value in the treatment of cancer.
Inventors:
Lawrence Hilton, Patterson
Application Number:
JP51427890A
Publication Date:
April 16, 1992
Filing Date:
October 12, 1990
Export Citation:
Assignee:
British Technology Group Limited
International Classes:
A61K31/22; A61P35/00; C07C225/36; C07C291/04; A61K31/135; C09B1/515; (IPC1-7): A61K31/135; A61K31/22; C07C225/36; C07C291/04
Attorney, Agent or Firm:
Kyozo Yuasa (8 outside)