Title:
【発明の名称】ハロゲン置換アミノテトラリン類
Document Type and Number:
Japanese Patent JPH04502620
Kind Code:
A
Abstract:
This invention is therapeutically useful tetralins and pharmaceutically acceptable acid addition salts thereof of formula (I), wherein X1 is halogen, CF3, -OR3, or -SR4; wherein R3 is alkyl(C1-C8); alkenyl(C1-C8), -CH2-cycloalkyl(C3-C8) or benzyl; wherein R4 is alkyl(C1-C3); wherein X2 is hydrogen, CF3 or halogen; wherein R7 is hydrogen or methyl; wherein R1 is hydrogen, alkyl(C1-C3), or cyclopropylmethyl; wherein R2 is -CH2-cycloalkyl(C3-C8), alkyl(C1-C8), -(CH2)q-R5 or -CH2CH2-Z-(CH2)rCH3; wherein R5 is phenyl, 2-thiophene or 3-thiophene; wherein Z is oxygen or sulfur; and wherein p is 1 or 2, q is 2 or 3, and r is 0 to 3; with the provisos that (1) when X1 is -OR3, X2 is halogen or CF3; and (2) when X1 is halogen, X2 is hydrogen, and p is 2, X1 is in a position other than the 8-position. These compounds are useful to treat central nervous system disorders.
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Inventors:
Carlson, P. Arbide Amir
Bigstrom, Harkan Wilhelm
Svenson, Cher Anders Ivan
Anderson, Bengt Ronnie
Akman, Akneta Barbello
Stojen Lev, Nils Peter
Nils Arne, Svenson
Bigstrom, Harkan Wilhelm
Svenson, Cher Anders Ivan
Anderson, Bengt Ronnie
Akman, Akneta Barbello
Stojen Lev, Nils Peter
Nils Arne, Svenson
Application Number:
JP50227290A
Publication Date:
May 14, 1992
Filing Date:
January 03, 1990
Export Citation:
Assignee:
The Up John Company
International Classes:
A61K31/135; A61K31/38; A61K31/381; A61P25/00; A61P25/18; A61P25/20; A61P25/24; C07D333/20; A61P25/26; A61P25/28; C07C211/42; C07C217/74; C07C323/25; C07C323/38; (IPC1-7): A61K31/135; A61K31/38; C07C211/42; C07C217/74; C07C323/25; C07C323/38; C07D333/20
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)