Document Type and Number:
Japanese Patent JPH045672
Kind Code:
B2
Abstract:
Novel 1,5-benzoxathiepin derivatives of the formula: [wherein R1 and R2 are independently hydrogen, halogen, hydroxy, lower alkyl or lower alkoxy; R3 and R4 are independently hydrogen, optionally substituted lower alkyl or optionally substituted cycloalkyl or optionally substituted aralkyl, or both jointly form an optionally substituted ring together with the adjacent nitrogen atom; X is hydrogen, optionally substituted lower alkyl, optionally substituted aryl or a carboxyl group which may be esterified or amidated; Y is &rdurule& C=O or &rdurule& CH-OR5 (wherein R5 is hydrogen, acyl or optionally substituted carbamoyl); m is an integer of 0 to 2; n is an integer of 1 to 6] and salts thereof exhibit serotonin S2 receptor blocking activity, calcium antagonism, actions to relieve cerebral vasospasm and to improve renal circulation and diuretic and antithrombotic activities, and are of value as a prophylactic and therapeutic agent for ischemic cardiopathies, thrombosis, hypertension and cerebral circulatory disorders.
Inventors:
SUGIHARA HIROSADA
HIRATA MINORU
HIRATA MINORU
Application Number:
JP3237589A
Publication Date:
February 03, 1992
Filing Date:
February 10, 1989
Export Citation:
Assignee:
TAKEDA CHEMICAL INDUSTRIES LTD (JP)
International Classes:
A61K31/385; A61K31/39; A61K31/495; A61P11/00; C07D327/02; C07D411/06; C07D411/12
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