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Document Type and Number:
Japanese Patent JPH0466879
Kind Code:
B2
Abstract:
Novel 19-nor steroids and 19-nor-D-homo-steroids of the formula I' wherein R1 is an organic radical of 1 to 18 carbon atoms containing at least one atom selected from the group consisting of nitrogen, phosphorous and silicon with the atom immediately adjacent to the 11-carbon atom being carbon, R2 is a hydrocarbon of 1 to 8 carbon atoms, X is selected from the group consisting of a pentagonal ring and a hexagonal ring optionally substituted and optionally containing a double bond, B and C together form a double bond or an epoxy group, the C=A group at position 3 is selected from the group consisting of C=O, ketal, which may be open or closed +TR CNOAlK3 and CCH2, AlK1, AlK2 and AlK3 are selected from the group consisting of alkyl of 1 to 8 carbon atoms and aralkyl of 7 to 15 carbon atoms and their non-toxic, pharmaceutically acceptable acid addition salts having anti-glucocorticoid activity and a process for their preparation.

Inventors:
JAN JORUJU TOOCHI
JERUMAN KOSUTORUUSU
DANIERU FUIRIBEERU
ROJE DORAE
Application Number:
JP6648889A
Publication Date:
October 26, 1992
Filing Date:
March 20, 1989
Export Citation:
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Assignee:
ROUSSEL UCLAF
International Classes:
C07J1/00; A61K31/565; A61K31/57; A61K31/58; A61P3/08; A61P5/38; A61P9/10; A61P9/12; A61P25/20; A61P37/04; A61P43/00; C07J7/00; C07J21/00; C07J41/00; C07J43/00; C07J51/00; C07J63/00; C07J71/00



 
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