Document Type and Number:
Japanese Patent JPH0513947
Kind Code:
B2
Abstract:
The invention relates to a process for preparing 2,3-dihydro-1H-imidazolylalkoxyindene derivatives and its pharmaceutically acceptable salts, characterized in that 5-methoxy-1-indanone is used as a starting compound, followed by formation of the corresponding cyanohydrine, treatment with stannous chloride to give 2,3-dihydro-5-methoxy-1H-indene-1-carboxylic acid, followed by subsequent demethylation of the methoxy group, protection of the carboxylic acid group by esterification, formation of the corresponding omega -chloroalkyl ether, reaction with imidazole and final hydrolysis, thus obtaining 2,3-dihydro-5-[ beta -(1H-imidazol-1-yl)-alkoxy]-1H-indene-1-carboxylic acid. The process gives the intermediates in high purity and high yields so that the intermediates can be further processed without purification which results in an elevated overall yield.
Inventors:
RAFUAERU FUOGETSUTO
ERUNESUTO FUORUNE
AURERIO SAKURISUTAN
JOSETSUPU EMU KASUTERO
JOSE EI ORUTEIZU
ERUNESUTO FUORUNE
AURERIO SAKURISUTAN
JOSETSUPU EMU KASUTERO
JOSE EI ORUTEIZU
Application Number:
JP394988A
Publication Date:
February 23, 1993
Filing Date:
January 13, 1988
Export Citation:
Assignee:
FERRER INT
International Classes:
A61K31/415; A61P7/02; C07C62/06; C07C62/14; C07C62/32; C07C62/34; C07C69/635; C07C69/757; C07C255/47; C07D233/60; C07D521/00; C07F7/18
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