Document Type and Number:
Japanese Patent JPH0518838
Kind Code:
B2
Abstract:
Two processes are disclosed (one-pot and two-pot) for the transformation of a 6 beta -fluoro- DELTA 1,4-3-keto steroid (IV) to a 6 alpha -fluoro- DELTA 1,4-3-keto steroid (VI). These processes permit the introduction of a fluorine atom at the 6 alpha position of a DELTA 1,4-3-keto steroid where previously the DELTA 1 double bond could not be introduced until after the 6 alpha -fluorine atom was present. The 6 alpha -fluoro- DELTA 1,4-3-keto steroids (VI) are intermediates useful in the production of pharmacologically active steroids.
Inventors:
KENESU HOORU SHEPAADO
Application Number:
JP7655290A
Publication Date:
March 15, 1993
Filing Date:
March 26, 1990
Export Citation:
Assignee:
UPJOHN CO
International Classes:
C07J1/00; A61K31/57; A61K31/58; A61K31/585; A61P29/00; C07J5/00; C07J7/00; C07J13/00; C07J17/00; C07J21/00; C07J71/00
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