Document Type and Number:
Japanese Patent JPH0529227
Kind Code:
B2
Abstract:
The invention relates to a novel process for the preparation of partially new 2-halonicergoline derivatives of the formula (I), (I) wherein X stands for chlorine, bromine or iodine atom, as well as their acid addition salts. The process of the invention comprises esterifying a novel 2-halo-1-methyllumilysergol of the formula (II), (II) wherein X is the same as defined above, or an acid addition salt thereof and, if desired, converting the thus-obtained 2-halonicergoline derivative of the formula (I) to an acid addition salt. The compounds of the invention improve the cognitive function of the brain and show an antihypoxic as well as a strong alpha -adrenerg blocking and calcium-antagonistic action.
Inventors:
GAABORU MEJEERI
TEIBORU KEBE
BEERA SUTEFUKOO
ERIKU BOGUSUCHU
YAANOSU KARAMUBOSU
ATSUNA KATSUSAI
FUERENTSU TORISHUCHURERU
EEBA PAAROSHUI
DOORA GUROO
EGON KAARUPAATEI
JUORUTO SOMUBATOHEII
RAASUROO SUHOR
TEIBORU KEBE
BEERA SUTEFUKOO
ERIKU BOGUSUCHU
YAANOSU KARAMUBOSU
ATSUNA KATSUSAI
FUERENTSU TORISHUCHURERU
EEBA PAAROSHUI
DOORA GUROO
EGON KAARUPAATEI
JUORUTO SOMUBATOHEII
RAASUROO SUHOR
Application Number:
JP14316286A
Publication Date:
April 28, 1993
Filing Date:
June 20, 1986
Export Citation:
Assignee:
RIHITAA GEDEON BEGIESUZECHI GIARU AARU TEII
International Classes:
A61K31/48; A61P3/00; A61P3/14; A61P9/00; A61P25/02; A61P25/28; C07D457/02
Next Patent: ATOMIC LAYER CRYSTAL DEPOSITION METHOD AND DEVICE