Document Type and Number:
Japanese Patent JPH0541638
Kind Code:
B2
Abstract:
17 beta -N-monosubstituted carbamoyl or 17 beta -acyl-4-aza-5 alpha -androst-1-en-3-ones of the formula: in which R is hydrogen, methyl or ethyl; R<2> is a C1-12 straight or branched alkyl radical or a monocyclic aryl optionally containing one or more methyl or ethyl substituents and/or one or more Cl, F or Br substituents; and in Formula IA R<2> may also be benzyl, phenethyl, 2-pyridyl, 4-pyridyl, 2-pyrrolyl, 2-furyl or thiophenyl; R min is hydrogen or methyl; R sec is hydrogen or beta -methyl and in Formula IA may also be alpha -methyl; and R''' is hydrogen, alpha -methyl or beta -methyl and pharmaceutical formulations containing the above compounds are active as testosterone 5 alpha -reductase inhibitors and thus are useful topically for treatment of acne, seborrhoea and female hirsutism, and systemically in the treatment of benign prostatic hypertrophy.
Inventors:
GYAREI ETSUCHI RASUMUSON
GUREN EFU REINORUZU
GUREN EFU REINORUZU
Application Number:
JP13534888A
Publication Date:
June 24, 1993
Filing Date:
June 01, 1988
Export Citation:
Assignee:
MERCK & CO INC
International Classes:
A61K31/58; A61P5/00; C07D213/00; C07C62/38; C07D221/18; C07J73/00; (IPC1-7): C07J73/00