Title:
【発明の名称】安定なヘモグロビンに基づく組成物及びその貯蔵方法
Document Type and Number:
Japanese Patent JPH05501729
Kind Code:
A
Abstract:
The present invention relates to a stable hemoglobin based composition having sufficiently low levels of methemoglobin to effectively function as an oxygen carrying solution upon administration to a patient made by the process comprising: a) adding an oxygenated or deoxygenated form of said blood substitute to an oxygen impermeable package, and b) storing said container at from between 5 DEG C to 45 DEG C for sufficient time to permit the autoreduction of methemoglobin. The stable hemoglobin based composition includes hemoglobin, modified hemoglobin and/or encapsulated hemoglobin. To effectively function as an oxygen carrying solution upon administration to a patient, the stable hemolobin based solution cannot have greater than about 50 % of said hemoglobin based solution in the methemoglobin form but, preferably no more than about 15 %. The invention further relates to a method to store a stable oxygen carrying solution according to the above discussed process.
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Inventors:
Chandler, richard, ell
Spicassa, John, Sea
Spicassa, John, Sea
Application Number:
JP51337691A
Publication Date:
April 02, 1993
Filing Date:
July 24, 1991
Export Citation:
Assignee:
Baxter, International, Inc.
International Classes:
A61K38/42; A61K38/16; A61P7/08; (IPC1-7): A61K37/14
Domestic Patent References:
| JP89006969Y |
Attorney, Agent or Firm:
Akaoka Mio