【発明の名称】RNA活性および遺伝子発現を検出および変調するための組成物および方法

Japanese Patent JPH05502031

A

Compositions and methods for modulating the activity of RNA and DNA are disclosed. In accordance with preferred embodiments, antisense compositions are prepared comprising targeting and reactive portions. Reactive portions which act, alternatively, through phosphorodiester bond cleavage, through backbone sugar bond cleavage or through base modification are preferably employed. Groups which improve the pharmacodynamic and pharmacokinetic properties of the oligonucleotides are also useful in accordance with certain embodiments of this invention. Delivery of the reactive or non-reactive functionalities into the minor groove formed by the hybridization of the composition with the target RNA is also preferably accomplished. Therapeutics, diagnostics and research methods are also disclosed. Synthetic nucleosides and nucleoside fragments are also provided useful for elaboration of oligonucleotides and oligonucleotide analogs for such purposes.

Cook, Philip Dunn
Ecker, David Jay
Charles John, Ginosso
Ascedo, Oscar Leopard
Kawasaki, Andrew Mamoto
Rama Sammy, Kanda Sammy

JP50339391A

April 15, 1993

January 11, 1991

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ISIS PHARMACEUTICALS INC (US)

A61K31/7042; A61K31/7052; A61K31/7056; A61K31/706; A61K31/7064; A61K31/7068; A61K31/7072; A61K31/7076; A61K31/708; A61K31/7088; A61K48/00; A61P31/12; A61P43/00; C07H19/00; C07H19/04; A61K31/70; C07H19/052; C07H19/056; C07H19/06; C07H19/10; C07H19/12; C07H19/14; C07H19/16; C07H19/19; C07H19/20; C07H19/23; C07H21/00; C07H21/02; C07H21/04; C07H23/00; C07J43/00; C07K14/16; C12N9/02; C12N15/09; C12N15/113; C12P21/00; C12Q1/68; C12Q1/70; A61K38/00; (IPC1-7): C12Q1/70; C12Q1/68; C12P21/00; C12N15/49; C12N15/38; C12N15/33; C07H21/04; C07H21/02; C07H19/23; C07H19/19; C07H19/16; C07H19/06; C07H19/056; C07H19/04; A61K48/00; A61K31/70

Kyozo Yuasa (5 people outside)

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