Title:
【発明の名称】末端封鎖された抗ウィルス性ペプチド
Document Type and Number:
Japanese Patent JPH05503535
Kind Code:
A
Abstract:
PCT No. PCT/US91/01142 Sec. 371 Date Aug. 28, 1992 Sec. 102(e) Date Aug. 28, 1992 PCT Filed Feb. 21, 1991 PCT Pub. No. WO91/13088 PCT Pub. Date Sep. 5, 1991.This invention relates to antiviral peptide compounds and to methods of inhibiting infection of human cells by viruses. This invention pertains more specifically to peptides that are chemically blocked at the amino- and carboxy-termini. In particular the invention relates to peptides comprised of prolylalanine or prolylphenylalanine compounds that have antiviral activity. The invention is specifically directed to methods for preventing infection of human cells in vivo and in vitro with the human immunodeficiency virus HIV-1 and methods for treating human infected with this and other viruses. The invention also relates to the diagnostic and therapeutic use of these antiviral peptide compounds.
Inventors:
Shreber, Stuart
Brakov, Stephen
Brakov, Stephen
Application Number:
JP50543791A
Publication Date:
June 10, 1993
Filing Date:
February 28, 1991
Export Citation:
Assignee:
President and Fellows of Harvard College
International Classes:
A61P31/12; C07K5/06; C07K5/078; C07K5/08; C07K5/097; A61K38/00; C07K5/12; C07K7/64; C12N7/06; (IPC1-7): A61K37/02; C07K5/06; C07K5/08; C07K5/12; C12N7/06
Attorney, Agent or Firm:
Hidekazu Miyoshi (1 outside)