Title:
【発明の名称】ラミニンの神経突起促進活性に対する阻害剤
Document Type and Number:
Japanese Patent JPH05504557
Kind Code:
A
Abstract:
The invention provides a purified proteoglycan-associated inhibitor of the neurite-promoting activity of laminin and a purified compound which: a) inhibits the neurite-promoting activity of purified rat, mouse, and human laminin; b) is active whether presented to laminin in solution or after either the inhibitor or laminin is first bound to the culture substratum; c) does not act by displacing laminin from the substratum; d) can be prevented from binding to neurite-promoting laminin substrates by polyclonal and some monoclonal anti-laminin or polyclonal anti-entactin antibodies if the laminin contains associated entactin; e) can be purified from rat RN22 Schwannoma cells; and f) neurite-promoting activity can be abolished by proteases or glycosaminoglycan lyases but not by heat at 90 DEG for 15 minutes.
Inventors:
Muir, david
Ingvar, Eva
Baron, Silvio
Manthorpe, Marston
Ingvar, Eva
Baron, Silvio
Manthorpe, Marston
Application Number:
JP51588190A
Publication Date:
July 15, 1993
Filing Date:
October 29, 1990
Export Citation:
Assignee:
LA JOLLA CANCER RESEARCH FOUNDATION
The Regents of The University of California
The Regents of The University of California
International Classes:
A61K38/00; A61K39/395; A61P25/00; A61P43/00; C07K14/435; C07K14/47; C07K16/18; (IPC1-7): A61K37/02; A61K39/395; C07K15/06
Attorney, Agent or Firm:
Shusaku Yamamoto