【発明の名称】ガス透過性耐血栓形成性被覆剤および製造方法

Japanese Patent JPH05504902

A

The present invention is directed to thrombo-resistant coatings for use with gas permeable biomedical devices and implants. The coatings include a siloxane surface onto which a plurality of amine functional groups have been bonded. Covalently bonded to the amine functional groups are a plurality of poly(ethylene oxide) chains, such that a single poly(ethylene oxide) chain is bonded to a single amine functional group. A quantity of at least one bioactive molecule designed to counteract a specific blood-material incompatibility reaction is covalently bonded to the poly(ethylene oxide) chains, such that a single bioactive molecule is coupled to a single polyethylene oxide chain. The methods of manufacturing the present invention include preparing a material having a siloxane surface onto which a plurality of amine functional groups have been bonded. This is preferably achieved by plasma etching with ammonia gas. The amine-containing siloxane surface is reacted with poly(ethylene oxide) chains terminated with functional groups capable of reacting with the amine groups on the siloxane surface. The material is then reacted with a solution of at least one bioactive molecule which counteracts a blood-material incompatibility reaction, such that a single bioactive molecule is coupled to a single poly(ethylene oxide) chain. The resulting siloxane surface is capable of resisting blood-material incompatibility reactions while maintaining high gas permeability.

Witters, Susan
Salen, Kenneth Ay
Sanders, Clifton Gee
Mortensen, Jay Dee
Berry, gaylord

JP50766091A

July 29, 1993

April 09, 1991

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Cardio Palmonics Incorporated

A61M1/16; B01D67/00; B01D69/12; A61L33/00; C08G65/32; C08G77/46; C08J7/04; C12N11/06; A61M1/36; (IPC1-7): C08J7/04; C08G77/46; C08G65/32; A61L33/00

Kyozo Yuasa (5 people outside)

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