Title:
【発明の名称】酸化的損傷に伴う疾患の阻止方法および組成物
Document Type and Number:
Japanese Patent JPH05505792
Kind Code:
A
Abstract:
Compositions containing as the active ingredient a spin-trapping reagent, preferably alpha -phenyl butyl nitrone (PBN) or spin-trapping derivatives thereof, in a suitable pharmaceutical carrier for administration to a patient are disclosed for treating or preventin symptoms associated with aging or other conditions associated with oxidative tissue damage. Other spin-trapping agents can also be used, such as 5,5-dimethyl pyrroline N-oxide (DMPO) or alpha -(4-pyridyl 1-oxide)-N-tert-butylnitrone (POBN), and other spin-trapping derivatives thereof. These compositions and methods are useful in the treatment of age-related disorders, pre-surgical and/or pre-anesthetic preparation or administration of chemotherapeutic agents, and in the treatment of disorders or trauma of the brain, cardiovascular system, and lymphatic system. Studies in animals demonstrate that administration of compound for a two week period reduces the level of oxidized brain enzymes ot normal and restores memory to the sam level as tested in young control animals.
Inventors:
Carney, John M.
Floyd, Robert A.
Floyd, Robert A.
Application Number:
JP51503690A
Publication Date:
August 26, 1993
Filing Date:
October 17, 1990
Export Citation:
Assignee:
OKLAHOMA MEDICAL RESEARCH FOUNDATION
UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION
UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION
International Classes:
A61K31/00; A61K31/135; A61K31/15; A61K31/16; A61K31/165; A61K31/167; A61K31/215; A61K31/13; A61K31/22; A61K31/222; A61K31/265; A61K31/325; A61K31/40; A61K31/44; A61K31/4409; A61K31/4418; A61K31/4425; A61P3/00; A61P3/10; A61P9/00; A61P9/10; A61P25/00; A61P25/02; A61P25/16; A61P25/28; A61P25/30; A61P29/00; A61P31/12; A61P39/06; A61P43/00; C07C251/32; C07C291/02; C07D207/46; C07D213/89; (IPC1-7): A61K31/22; A61K31/13; A61K31/16; A61K31/165; A61K31/265; A61K31/40
Attorney, Agent or Firm:
Hidesaku Yamamoto