Title:
【発明の名称】多発性硬化症T細胞受容体
Document Type and Number:
Japanese Patent JPH05507911
Kind Code:
A
Abstract:
This invention is directed to therapeutic agents comprising peptides in turn comprising a portion of the T-cell manifested in multiple sclerosis. Embodiments of the invention include peptides, vaccines, receptors and entire (attenuated) T-cells. This invention is also directed to methods using the foregoing agents to suppress immune response against myelin basic protein, and/or to suppress T-cells that recognize an immunodominant epitope of human myelin basic protein. Additionally, this invention is directed to diagnostic methods and kits for diagnosing multiple sclerosis.
Inventors:
Uchafenning, Kai Wu
Weyner, Howard El
Huffler, David Allen
Weyner, Howard El
Huffler, David Allen
Application Number:
JP50934791A
Publication Date:
November 11, 1993
Filing Date:
March 29, 1991
Export Citation:
Assignee:
Bringham and Wimins Hospital
Auto imune ink
Auto imune ink
International Classes:
A61K38/17; A61K39/00; A61P25/00; A61P37/06; C07K7/06; C07K7/08; C07K14/725; C12N5/08; C12N5/10; A61K38/00; C12N15/09; C12Q1/68; G01N33/53; A61K38/095; (IPC1-7): C07K7/08; A61K37/02; A61K39/00; C07K7/06; C12N5/08; C12N5/10; C12N15/11; C12Q1/68; G01N33/53
Attorney, Agent or Firm:
Masatake Shiga (2 outside)