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Title:
【発明の名称】Pt含有化合物、その合成方法及びこれらの化合物の応用
Document Type and Number:
Japanese Patent JPH05508853
Kind Code:
A
Abstract:
PCT No. PCT/NL91/00126 Sec. 371 Date Oct. 29, 1993 Sec. 102(e) Date Oct. 29, 1993 PCT Filed Jul. 16, 1991 PCT Pub. No. WO92/01699 PCT Pub. Date Jun. 2, 1992Pt-containing compound with the formula {PtII(w)(x)(y)(z)} or {PtIV(u)(v)(w)(x)(y)(z)}, wherein u, v, w, x, y and z represent whether or not the same whether or not interconnected ligands, of which at least one is a leaving ligand and at least one of the remaining ligands represents a detectable marker group. According to the invention (CH3)2SO, Cl or H2O appears to be suitable as a leaving ligand while as detectable marker group a fluorescent group merits preference and is the ligand fluorescein or tetramethyl rhodamine. A suitable Pt-containing compounds is {Pt(ethylenediamine)(Me2SO)(fluorescein-NH(CS)-NHCH3)} (PtF). Further, the invention comprises a process for the preparation of the Pt-containing compounds, where the Pt-containing compounds are prepared in a manner known per se for analogous compounds.

Inventors:
Juan den Berg, Francis Cass Michel
Lempers, Edvuin Leo Mario
Broemink, Mariek Johanna
Lee Dake, Yang
Application Number:
JP51258291A
Publication Date:
December 09, 1993
Filing Date:
July 16, 1991
Export Citation:
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Assignee:
Stechteng Clinicier Reze Archi Academia Missile Medicille Centrum
Likes Universitite Leiden
International Classes:
C07F15/00; C07H21/00; C07H23/00; G01N33/53; C07J51/00; C09B11/04; C12N15/09; C12Q1/68; C12Q1/6816; G01N33/532; G01N33/533; G01N33/566; G01N33/58; (IPC1-7): C07F15/00; G01N33/53; G01N33/533
Attorney, Agent or Firm:
Toshio Takayama



 
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