Document Type and Number:
Japanese Patent JPH0556349
Kind Code:
B2
Abstract:
1. A process for the preparation of 2-bromo-8-ergolinyl compounds of the formula I see diagramm : EP0141387,P4,F4 wherein R**8 is NH2 , NH-CONE2-t , CONH2 , see diagramm : EP0141387,P4,F5 and see diagramm : EP0141387,P5,F1 wherein R**1 is C1-4 -alkyl, and R**2 is C1-4 -alkyl and benzyl, R**9 and R**10 each are hydrogen or together form a bond, and the substituent R**8 may be in the alpha- or beta-position, and the acid additions salts thereof, from corresponding 8-ergolinyl compounds that are unbrominated in the 2-position, and acid addition salts thereof, by bromination, characterised in that the bromination is carried out with elemental bromine in the presence of hydrogen bromide, in a halogenated hydrocarbon as solvent, and, if desired, the acid addition salt is subsequently prepared.
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Inventors:
HERUMUUTO BERUNAA
GUREGOORU HAFUAA
GERUHARUTO ZAUAA
GUREGOORU HAFUAA
GERUHARUTO ZAUAA
Application Number:
JP22905084A
Publication Date:
August 19, 1993
Filing Date:
November 01, 1984
Export Citation:
Assignee:
SCHERING AG
International Classes:
C07D457/06; C07D457/12; C07D498/04; C07D519/02; (IPC1-7): C07D457/06; C07D457/12; C07D519/02