Japanese Patent JPH0586190

B2

The invention relates to a process for the conversion of corrinoids produced by microorganisms into cyanocorrinoids by reaction with cyanides. According to the invention a fermentation broth obtained by disruption of microorganism cells in a known manner, preferably by heat treatment in the presence or absence of sulfite ions, optionally after purification steps known per se, is contacted with a suitable adsorbent or ion exchange resin, the corrinoids adsorbed on the surface of the adsorbent or ion exchange resin are treated with an aqueous solution containing cyanide ions or a compound capable of supplying cyanide ions, in an amount providing cyanide ions in a 1.1 to 2.0-fold molar excess related to the corrinoids, the adsorbent or ion exchange resin is washed with water, and the cyanocorrinoids obtained is eluted in a known manner, preferably with aqueous ethanol.

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AAGUNESU KEREMEN
UDOBARUDEI NAGI ISUTOBAN DOKUT
ISUTOBAN IAKUSA

JP20722084A

December 10, 1993

October 04, 1984

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RICHTER GEDEON VEGYESZET

C07D487/22; C07H23/00; C12P17/18; C12P19/42; C12R1/01; C12R1/15; C12R1/225; (IPC1-7): C12P19/42; C07H23/00

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