Title:
【発明の名称】オリゴ(α―アラビノフラノシル・ヌクレオチド)およびそれらのα―アラビノフラノシル前駆体
Document Type and Number:
Japanese Patent JPH06500107
Kind Code:
A
Abstract:
Novel oligonucleotides formed from alpha -D-arabinofuranosyl nucleoside monomers, including oligonucleotides in which one or more of the monomer units is functionalized, are disclosed herein, as well as functionalized monomeric alpha -D-arabinofuranosyl nucleosides and nucleotides. A generic formula for the oligomers is: in which B is a nucleotide base which will vary from one monomeric unit to the next in a preselected oligonucleotide sequence; R is phosphate, phsophorothioate, phosphoramidate, or alkanephosphonate; t is 1 for functionalized monomeric units and zero for the others; W is a chemical linker arm; A is a functional group; and n is the number of monomeric units in the oligomer. The oligomers are useful for diagnostic and chemotherapeutic uses. A novel reaction is also disclosed, in which an alpha -D-arabinofuranosyl nucleoside with exposed hydroxyls at the 2'- and 3'-positions is selectively protected at the 2'-position in a single reaction.
Inventors:
Mayer, Richard Bee
Adams, A. David
Petrie, Charles Robert
Adams, A. David
Petrie, Charles Robert
Application Number:
JP51475791A
Publication Date:
January 06, 1994
Filing Date:
August 14, 1991
Export Citation:
Assignee:
Microprobe Corporation
International Classes:
C07H19/09; C07H19/06; C07H19/10; C07H19/16; C07H19/19; C07H19/20; C07H19/23; C07H21/00; C07H23/00; C12Q1/68; G01N33/50; G01N33/58; (IPC1-7): C07H21/00; C07H19/09; C07H19/19; C07H19/23; C12Q1/68; G01N33/50; G01N33/58
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)