Title:
【発明の名称】毒物保護化合物、組成物及び方法
Document Type and Number:
Japanese Patent JPH06500113
Kind Code:
A
Abstract:
Novel and known compounds are identified which possess protective properties against the toxic effects of electrophilic agents upon human and/or animal bodies, and the use of these compounds for the production of compositions for the protection of such bodies against those electrophiles is particularly provided. The compounds and compositions are effective against topically or systemically administered agents which are themselves electrophiles or which are metabolised to produce electrophilic products in the body. A particularly advantageous aspect of the present invention lies in the application of these compounds and compositions as protectants against inhaled electrophiles and their precursors. Some radioprotectant activity against intracellularly produced electrophiles will be provided due to the ability of the compounds to raise intracellular cysteine levels.
Inventors:
Apsial, David Grindwer
Roanston, Ian William
Roanston, Ian William
Application Number:
JP51549291A
Publication Date:
January 06, 1994
Filing Date:
August 30, 1991
Export Citation:
Assignee:
British country
International Classes:
A61K9/12; A61K9/127; A61K31/215; A61K31/22; A61K31/24; A61P39/02; A61P43/00; C07C323/58; (IPC1-7): A61K31/22; A61K9/12; A61K9/127; A61K31/22
Attorney, Agent or Firm:
Yoshio Kawaguchi (3 outside)