Title:
【発明の名称】ヒトマクロファージ炎症性タンパク質2β
Document Type and Number:
Japanese Patent JPH06501244
Kind Code:
A
Abstract:
An attempt to identify the human counterpart of murine macrophage inflammatory protein 2 unexpectedly resulted in not one but two candidate sequences, designated hu-MIP-2 alpha and hu-MIP- beta , respectively. By using the DNA sequences and recombinant systems provided by this invention, one can obtain hu-MIP-2 beta , one of the two human counterparts to mMIP-2, substantially free of other human protein. This invention also provides antibodies reactive with hu-MIP-2 DOLLAR (b) polypeptides as well as immunoassay methods for determining hu-MIP-2 beta and nucleotide probes for detecting nucleotide sequences encoding hu-MIP-2 beta in biological samples.
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Inventors:
Tecamp-Olson, Patricia
Galegos, Carol Ann
Galegos, Carol Ann
Application Number:
JP51243291A
Publication Date:
February 10, 1994
Filing Date:
June 24, 1991
Export Citation:
Assignee:
Chiron Corporation
International Classes:
A61K39/395; A61P29/00; A61P35/00; A61P37/00; C07K14/00; C07K14/52; C07K16/24; C12N5/10; C12N15/09; A61K38/21; C12N15/19; C12P21/02; C12P21/08; C12Q1/68; G01N33/53; A61K38/00; (IPC1-7): C07K15/12; A61K37/66; A61K39/395; C07K15/14; C12N5/10; C12N15/19; C12P21/02; C12P21/08; C12Q1/68; G01N33/53
Attorney, Agent or Firm:
Kyozo Yuasa (5 people outside)