Title:
【発明の名称】サイトメガウイルス感染の作用を変調するオリゴヌクレオチド
Document Type and Number:
Japanese Patent JPH06501841
Kind Code:
A
Abstract:
PCT No. PCT/US91/05815 Sec. 371 Date Nov. 19, 1992 Sec. 102(e) Date Nov. 19, 1992 PCT Filed Aug. 14, 1991Compositions and methods for modulating the effects of cytomegalovirus (CMV) infections are disclosed, comprising contacting CMV mRNA with an oligonucleotide or oligonucleotide analog which can bind with at least portions of the CMV RNA. In accordance with the preferred embodiments, oligonucleotides or oligonucleotide analogs are designed to bind with portions of the CMV mRNAs which code for the IE1, IE2 or DNA polymerase proteins. In accordance with a preferred embodiment, methods of treatment of human cytomegalovirus are disclosed.
Inventors:
Anderson, Kevin Pea
Drapper, Kennis Gee
Drapper, Kennis Gee
Application Number:
JP51377691A
Publication Date:
March 03, 1994
Filing Date:
August 14, 1991
Export Citation:
Assignee:
Isis PharmaceuticalsInc
International Classes:
A01N43/04; A61K48/00; A61P31/12; A61K31/70; C07H15/12; C07H17/00; C07H21/00; C07K14/045; C12N9/12; C12N15/00; C12N15/09; C12N15/113; C12P19/34; C12Q1/68; C12Q1/70; A61K38/00; C07H; (IPC1-7): C12N15/11; C12N15/38; C12Q1/68
Attorney, Agent or Firm:
Kyozo Yuasa (5 people outside)