Title:
【発明の名称】架橋環状ケタール誘導体
Document Type and Number:
Japanese Patent JPH06504529
Kind Code:
A
Abstract:
Compounds are described of the formula wherein R<1> represents a hydrogen atom or a hydroxyl, acyloxy, carbonate, carbamate or ether group; R<2> represents a hydrogen atom, a hydroxyl group, a group -OCOR<7> or a group -OCO2R<7> (where R<7> is a group selected from C1-8alkyl, aryl, arylC1-4alkyl and C3-8cycloalkyl); R<3> represents a group selected from (where the dotted line represents the absence or presence of a single bond, R<8> represents a hydrogen atom or a hydroxyl, acyloxy, C1-6alkoxy or C1-4alkyl group, R<9> represents a hydrogen atom and R<1><0> represents a hydrogen atom or a hydroxyl, C1-6alkoxy or acyloxy group or CR<9>R<1><0> forms a group C=0, R<1><1> represents a hydrogen atom or a C1-4alkyl group, R<1><2> represents a hydrogen atom or a methyl group, R<1><3> represents a hydrogen atom or a hydroxyl group, m represents 1 or 2 and n represents zero or 1); R<4> and R<5> may each independently represent a hydrogen atom or a methyl group; R<6> represents a hydrogen atom or a hydroxymethyl group; and salts thereof; with the proviso R<1> and R<2> cannot both represent hydrogen atoms. These compounds inhibit the enzyme squalene synthase and/or are intermediates for the preparation of compounds which inhibit the enzyme squalene synthase. Compounds of the invention may be formulated for use in a variety of conditions where a lowering of the level of blood plasma cholesterol in animals would be beneficial and for use in combating fungal infections in animals.
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Inventors:
Push-tie, Arpad Janos
Prokopiu, Panayotis Alexandrou
Lester, Michael George
Watson, Nigel Stephen
Kirk, Barry Edward
Quaken Bush, Allen, Bee.
Cox, brian
Ern, Hearne
Ross, Barry Clive
Prokopiu, Panayotis Alexandrou
Lester, Michael George
Watson, Nigel Stephen
Kirk, Barry Edward
Quaken Bush, Allen, Bee.
Cox, brian
Ern, Hearne
Ross, Barry Clive
Application Number:
JP50167092A
Publication Date:
May 26, 1994
Filing Date:
January 07, 1992
Export Citation:
Assignee:
GLAXO GROUP LTD.
International Classes:
A61P3/06; C07D493/08; C07H9/04; A61K31/34; C07H19/01; C12N9/99; C12P17/18; (IPC1-7): C07D493/08; A61K31/34
Attorney, Agent or Firm:
Kazuo Sato (2 outside)